The South African Centre for Epidemiological Modelling and Analysis (SACEMA) was founded in 2006 as a DST-NRF Centre of Excellence and is hosted at Stellenbosch University in the Western Cape. SACEMA is a national research centre dedicated to integrating models and data to advance fundamental understanding of health at the population level and to inform public health decision-making.

SACEMA is located in a rennovated wine cellar on the grounds of the Mostertsdrift Estate and provides research facilities and a stimulating environment in which scientists can interact productively to transcend disciplinary and institutional boundaries.